Synthesis and Antimicrobial Activity of Schiff’s and N-Mannich Bases of Indoline 2, 3-Dione and Its Derivatives with N-(4-(4-Aminophenylsulphonyl) Phenyl) Acetamide

Indoline 2, 3-dione and substituted Indoline 2, 3-dione derivatives were reacted with N-(4-(4-aminophenylsulphonyl) phenyl) acetamide to generate a variety of Schiff's bases. Using these compounds' Mannich bases were created by reacting them with formaldehyde and secondary amine (piperidine). The compounds were all described using IR, 1H NMR spectroscopic data and elemental analysis. The antibacterial activity of the produced compounds was determined using the tube dilution and Well plate methods. When compound UNS-2 was incubated at concentrations of 100, 50, and 25mg/ml, it showed the greatest Zone of Inhibition against Enterococcus faecalis. When compared to the reference medication, all of the synthesised compounds demonstrated superior antimicrobial efficacy.