Insight into the potential role of ferroptosis in neurodegenerative diseases

Ji, Yingying and Zheng, Kai and Li, Shiming and Ren, Caili and Shen, Ying and Tian, Lin and Zhu, Haohao and Zhou, Zhenhe and Jiang, Ying (2022) Insight into the potential role of ferroptosis in neurodegenerative diseases. Frontiers in Cellular Neuroscience, 16. ISSN 1662-5102

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Abstract

Ferroptosis is a newly discovered way of programmed cell death, mainly caused by the accumulation of iron-dependent lipid peroxides in cells, which is morphologically, biochemically and genetically different from the previously reported apoptosis, necrosis and autophagy. Studies have found that ferroptosis plays a key role in the occurrence and development of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and vascular dementia, which suggest that ferroptosis may be involved in regulating the progression of neurodegenerative diseases. At present, on the underlying mechanism of ferroptosis in neurodegenerative diseases is still unclear, and relevant research is urgently needed to clarify the regulatory mechanism and provide the possibility for the development of agents targeting ferroptosis. This review focused on the regulatory mechanism of ferroptosis and its various effects in neurodegenerative diseases, in order to provide reference for the research on ferroptosis in neurodegenerative diseases.

Item Type: Article
Subjects: ScienceOpen Library > Medical Science
Depositing User: Managing Editor
Date Deposited: 30 Mar 2023 06:33
Last Modified: 05 Jul 2024 07:52
URI: http://scholar.researcherseuropeans.com/id/eprint/835

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