Updates in Diagnosis and Management of Neonatal Cholestasis

Hamed, Nazim Faisal and Alyasi, Alaa Saud M. and Bedaiwi, Abdulaziz Abdulrahman Abdulqader and Alshehri, Turki Saleh and Ali, A. Asseri Muhand and Alenaze, Amer Faisal Alqaishesh and Albanaqi, Ihtifal Salamh and Alenezi, Almhnd Talal F. and Alanazi, Khaled Abdulaziz and Kharaan, Zaid Ibrahim Z. Al and Alhamwan, Kawthar Fawaz Mansor and Alshahrani, Mohammed Salem Slman and Obaid, Ahmed Basheer Ahmed Al (2021) Updates in Diagnosis and Management of Neonatal Cholestasis. Journal of Pharmaceutical Research International, 33 (60B). pp. 1078-1085. ISSN 2456-9119

[thumbnail of 6752-Article Text-9171-1-10-20221006.pdf] Text
6752-Article Text-9171-1-10-20221006.pdf - Published Version

Download (399kB)

Abstract

Neonatal jaundice refers to the yellow coloration of the skin and sclera of newborn babies that results from hyperbilirubinemia. About 50% of term and 80% of preterm babies develop jaundice in the first week of life. Jaundice is also a common cause of readmission to hospital after early discharge of newborn babies. Jaundice mainly develop due to two factors—the cessation of fetal hemoglobin as it is substituted with adult hemoglobin and the comparatively immature metabolic trails of the liver, which are incapable to conjugate and so expel bilirubin as quickly as an adult. This grounds an accretion of bilirubin in the blood (hyperbilirubinemia), causes the symptoms of jaundice. The typical results in an infant who has cholestasis are prolonged jaundice, scleral icterus, acholic stools, dark yellow urine, and hepatomegaly. Trying of diagnosis of children with jaundice must begin with the classification of serum bilirubin into total bilirubin and direct (or combined) bilirubin. Phototherapy is introduced based on risk influences in the nomogram and serum bilirubin levels. IV immunoglobulin is suggested for cumulative bilirubin levels from isoimmune hemolysis regardless of phototherapyand exchange transfusion is designated if there is a risk of neurologic dysfunction regardless beginning of phototherapy. This review aims to summarize current evidence regarding epidemiology, etiology, diagnosis and management of neonatal cholestasis.

Item Type: Article
Subjects: ScienceOpen Library > Medical Science
Depositing User: Managing Editor
Date Deposited: 27 Mar 2023 06:04
Last Modified: 19 Jul 2024 07:45
URI: http://scholar.researcherseuropeans.com/id/eprint/398

Actions (login required)

View Item
View Item