Prevalence of Gene Polymorphism for Menopausal Women with Cardiovascular Disease: A Study from Punjab, India

The present study was aimed to screen the prevalence of +276 G/T polymorphism of AdipoQ gene in menopausal women of Punjab with and without the family history of cardiovascular disease (CVD) and whether positive family history of CVD does have any specific independent effect on cardiovascular disease in menopausal women of Indian Punjabi descent. A total of 265 menopausal women with CVD as cases and 258 menopausal women without CVD as controls were recruited from Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab (India). Several factors or mechanisms could interfere in the association between ADIPOQ SNPs, adiponectin levels and cardiometabolic diseases. Prevalence of family history varies depending upon the age at which it is assessed. Familial aggregation of CVD may be related to assembly of specific risk factors as mentioned above or specific behaviors such as smoking and alcohol use that may have genetic and environmental influences. Study also shows TT genotype of recessive model of inheritance of cases with positive family h/o of CVD conferred ~6 fold high risk for CVD as compared to controls. It is concluded that prevalence of TT genotype was found to be more in cases as compared to controls both in women with and without family h/o CVD. New therapeutic interventions can also be developed to limit the burden of disease. Furthermore, strong need for increased public health care system is also required.