Exploring the Plant Based Extracts for Treatment of Diabetic Caused by Steroids

The present study was evaluate the hypoglycemic and hypolipidemic effect of ethyl acetate (EAEPC) and ethanolic (EEPC) extracts from fruits of Pyrus communis by dexamethasone-induced diabetic rats. Chronic hyperglycemia during diabetes causes glycation of body proteins that in turn leads to secondary complications affecting eyes, kidneys, nerves and arteries. The different groups of animals were induced for diabetes with dexamethasone (10 mg/kg bw- sc) once daily for 11 days except normal control. The extracts 200mg/kg and glibenclamide 5mg/kg was administered to treat the diabetic rats once daily for 11 days. When compared to the diabetic control, the treated groups demonstrated significant (p<0.01) anti-diabetic and hypolipidemic activity. The extracts have the same beneficial effects on blood glucose levels as the standard. Additionally, it maintains body weight while lowering elevated levels of triglycerides (TGL), low density lipoproteins (LDL), very low density lipoproteins (VLDL), and total cholesterol (TC). It also increases low levels of high density lipoprotein (HDL). We came to the conclusion that both extracts had the potential to be effective oral hypoglycemic medications and showed promise for the creation of phytomedicines for diabetes mellitus and its complications.