Association of Polymorphisms in DAZL Gene with Male Infertility

Khabour, Omar F. and Al-azzam, Akram M. and Alfaouri, Almuthana A. and Zayed, Faheem (2012) Association of Polymorphisms in DAZL Gene with Male Infertility. British Journal of Medicine and Medical Research, 3 (1). pp. 41-48. ISSN 22310614

[thumbnail of Khabour+et+al_312012BJMMR2009.pdf]

Text
Khabour+et+al_312012BJMMR2009.pdf - Published Version
Download (210kB)

Official URL: https://doi.org/10.9734/BJMMR/2013/2009

Abstract

Objectives: To investigate the association between A260G (Thr12Ala) and A386G (Thr54Ala) single nucleotide polymorphisms (SNPs) in deleted in azoospermia-like gene (DAZL) and infertility in Jordanian males.
Methods: Infertile 170 patients with azoospermia or oligozoospermia and 176 fertile subjects were recruited in the study. DAZL SNPs were genotyped using polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP).
Results: The data showed that the A260G SNP is common in the Jordanian population with frequency of 10.3% for 260G mutant allele. However, the A386G SNP is absent in the studied population. No significant association was found between the examined SNPs in DAZL gene and men infertility.
Conclusion: The A260G and A386G polymorphisms of DAZL seem to play no role in men infertility in Jordanian population.

Item Type:	Article
Subjects:	ScienceOpen Library > Medical Science
Depositing User:	Managing Editor
Date Deposited:	28 Jun 2023 04:29
Last Modified:	26 Jul 2024 06:48
URI:	http://scholar.researcherseuropeans.com/id/eprint/1626

Actions (login required)

: View Item