Signaling by adenosine receptors—Homeostatic or allostatic control?

Cunha, Rodrigo A. (2019) Signaling by adenosine receptors—Homeostatic or allostatic control? PLOS Biology, 17 (4). e3000213. ISSN 1545-7885

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Abstract

Adenosine modulation is considered both a paracrine signal coordinating different cells in a tissue and a stress signal. Both functions are ensured by 4 types of adenosine receptors (ARs), which have been studied individually. Mice with knockout of all ARs (quad-AR-KO) now allow enquiring the overall function of the adenosine modulation system. The observed “normal” physiology of quad-AR-KO mice indicates that ARs do not regulate homeostasis and are likely recruited to selectively control allostasis.

Item Type: Article
Subjects: ScienceOpen Library > Biological Science
Depositing User: Managing Editor
Date Deposited: 07 Jan 2023 09:00
Last Modified: 01 Jul 2024 09:13
URI: http://scholar.researcherseuropeans.com/id/eprint/153

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