Cunha, Rodrigo A. (2019) Signaling by adenosine receptors—Homeostatic or allostatic control? PLOS Biology, 17 (4). e3000213. ISSN 1545-7885
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Official URL: https://doi.org/10.1371/journal.pbio.3000213
Abstract
Adenosine modulation is considered both a paracrine signal coordinating different cells in a tissue and a stress signal. Both functions are ensured by 4 types of adenosine receptors (ARs), which have been studied individually. Mice with knockout of all ARs (quad-AR-KO) now allow enquiring the overall function of the adenosine modulation system. The observed “normal” physiology of quad-AR-KO mice indicates that ARs do not regulate homeostasis and are likely recruited to selectively control allostasis.
Item Type: | Article |
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Subjects: | ScienceOpen Library > Biological Science |
Depositing User: | Managing Editor |
Date Deposited: | 07 Jan 2023 09:00 |
Last Modified: | 01 Jul 2024 09:13 |
URI: | http://scholar.researcherseuropeans.com/id/eprint/153 |