Acetylome in Human Fibroblasts From Parkinson's Disease Patients

Yakhine-Diop, Sokhna M. S. and Rodríguez-Arribas, Mario and Martínez-Chacón, Guadalupe and Uribe-Carretero, Elisabet and Gómez-Sánchez, Rubén and Aiastui, Ana and López de Munain, Adolfo and Bravo-San Pedro, José M. and Niso-Santano, Mireia and González-Polo, Rosa A. and Fuentes, José M. (2018) Acetylome in Human Fibroblasts From Parkinson's Disease Patients. Frontiers in Cellular Neuroscience, 12. ISSN 1662-5102

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Abstract

Parkinson's disease (PD) is a multifactorial neurodegenerative disorder. The pathogenesis of this disease is associated with gene and environmental factors. Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent genetic cause of familial and sporadic PD. Moreover, posttranslational modifications, including protein acetylation, are involved in the molecular mechanism of PD. Acetylation of lysine proteins is a dynamic process that is modulated in PD. In this descriptive study, we characterized the acetylated proteins and peptides in primary fibroblasts from idiopathic PD (IPD) and genetic PD harboring G2019S or R1441G LRRK2 mutations. Identified acetylated peptides are modulated between individuals' groups. Although acetylated nuclear proteins are the most represented in cells, they are hypoacetylated in IPD. Results display that the level of hyperacetylated and hypoacetylated peptides are, respectively, enhanced in genetic PD and in IPD cells.

Item Type: Article
Subjects: ScienceOpen Library > Medical Science
Depositing User: Managing Editor
Date Deposited: 02 Jun 2023 04:24
Last Modified: 28 Oct 2024 08:07
URI: http://scholar.researcherseuropeans.com/id/eprint/1414

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