Effects of Sodium Selenite on Formaldehyde Induced Renal Toxicity in Mice

Mohammadi, Shabnam and Moghimian, Maryam and Torabzadeh, Hanieh and Langari, Mahla and Nazeri, Roghayeh and Karimi, Zahra and Sangari, Elham and Jagarmi, Najmeh and Mohammad Zadeh, Alireza and Karimi, Mehdi and Tavakkoli, Kamyar and Delshad, Ali and Mohammadzadeh, Fatemeh and Ghayour-Mobarhan, Majid (2016) Effects of Sodium Selenite on Formaldehyde Induced Renal Toxicity in Mice. Pharmaceutical Sciences, 22 (4). pp. 227-233. ISSN 1735-403X

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Abstract

Background: Formaldehyde is widely used for industrial applications. Renal injury is an adverse effect associated with formaldehyde. Few studies have explored the potential benefits of protective factors on formaldehyde induced renal toxicity. This study evaluated the dose dependent effects of sodium selenite on the biochemical and histopathological effects of formaldehyde on murine kidney. Methods: Forty eight adult Balb/c male mice were randomized into six groups: a control group, a formaldehyde group and experimental III-VI groups. Formaldehyde group was injected with 10 mg/kg formaldehyde and groups III-VI received intraperitoneally doses of 0.1, 0.2, 0.4, 0.8 mg/kg selenium. After two weeks, a stereological study was done in accordance with the principle of Cavalieri and serum concentrations of urea and creatinine were measured. Data were analyzed using ANOVA and SPSS software. Results: Glomerosclerosis, necrosis and vacuolization were observed in the convoluted tubules of animals treated with formaldehyde. The biochemical markers, volume and count of glomeruli in the group treated with formaldehyde was significantly difference compared to the control group (P<0.05). The volume of the glomeruli in the group treated with 0.2 and 0.4 mg selenium and urea level in the group treated with 0.4 and 0.1 mg/kg selenium was significantly difference compared to the control group (P <0.05). The count of glomeruli and creatinine level in the selenium group was significantly difference compared to the control group (P ≤ 0.0001). Conclusions: A dose of 0.2 mg/kg of sodium selenite caused partial protective effect on the renal tissue and function in exposed to formaldehyde.

Item Type: Article
Subjects: ScienceOpen Library > Medical Science
Depositing User: Managing Editor
Date Deposited: 09 May 2023 05:28
Last Modified: 19 Oct 2024 03:55
URI: http://scholar.researcherseuropeans.com/id/eprint/1199

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