Gastroprotective Effect of Nanocurcumin Particles against Indomethacin-induced Gastric Ulcer in Mice

This study aims to investigate the gastroprotective properties of nanocurcumin against indomethacin-induced gastric ulcer in mice. Nanocurcumin particles were prepared by top down method, yielding up to 15% (w/w), and the size was defined less than 100 nm in diameter. The particles were characterized by using scanning electron microscope (SEM), transmission electron microscope (TEM), dynamic laser light scattering (DLS), and X-ray diffraction (XRD). Significant gastroprotective properties of prepared nanocurcumin against indomethacin-induced stomach ulcer in mice (20 mg/kg, body weight) was observed by evaluating the levels of LPO, GSH, CAL and total protein in stomach and histological examining stomach of mice. It is believed that nanocurcumin particles are capable of healing mucosal injury inhibiting acid secretion, and reducing free radicals against indomethacin-induced injury stomach in mice.