Antiretroviral Therapy Immune Function Reinstallation in HIV-Infection in Sub Sahara Africa Population

Alisi, Precious Nc. and Ibegbulem, Edna O. and Eze, Evelyn M. and Alisi, Chinwe S. and Jeremiah, Zacchaeus A. (2021) Antiretroviral Therapy Immune Function Reinstallation in HIV-Infection in Sub Sahara Africa Population. Asian Hematology Research Journal, 5 (3). pp. 1-11.

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Abstract

Aims: To access antiretroviral therapy immune function reinstallation in HIV-infection in a sub-Sahara Africa population.

Study Design: The study was carried out in HIV seronegative healthy young (20-35 years) adults (CTRL), HIV Seropositive ART-Naive (20-35 years) young adults (Naïve) and HIV Seropositive on Anti-retroviral therapy (ART) aged 20-35 years old.

Place and Duration of Study: One hundred and fifty subjects were used for the study. One hundred (100) are HIV seropositive individuals, 50 on ART and 50 ART-Naive attending the Federal Medical Centre Owerri between August and December 2020. Fifty (50) healthy younger adults of the same age range served as controls in this study.

Methodology: EDTA and plain vacutainers were used to collect Venous blood from each participant. The following parameters were determined in the subjects: Viral load, CD4+, CD8+, CD4+/CD8+ ratio was calculated and CD57+ measured, Erythrocyte Sedimentation rate (ESR), and C-reactive protein (CRP) concentrations were also determined in subjects. The data generated were analysed by a one-way analysis of variances (ANOVA) using Statistical Package for Social Sciences (SPSS) version 21.

Results: The result of the study showed that Naïve individuals had a mean viral load of 41.54±13.39 copies/ml (IQR12-18) while subjects on ART had a significantly (p<0.05) lower mean viral load value of 22.26±11.31 (IQR8-54). CD4+ count obtained was 335.46 ± 76.75, 482.80 ± 88.69 and 846.08 ± 231.47cells/mm3 in NAIVE, ART and Control subjects respectively. CD8+ count obtained was 604.34 ± 126.09, 441.48 ± 94.42 and 376.86 ± 51.17 cells/mm3 in NAÏVE, ART and CTRL,respectively. Our result showed that HIV infection significantly (P<0.05) decreased CD4+/CD8+ ratio. CD57+ counts in ART treated subjects were found to be improved by treatment. CD4+ count correlated positively with viral load in NAÏVE (r = 0.799) and in ART subjects (r = 0.809). ART-NAÏVE, ART and CTRL subjects had IFN-γ concentrations of 186.44 ± 38.67, 161.83 ± 37.34 and 133.73 ± 25.97 pg/ml respectively. ESR was significantly (P<0.05) elevated in HIV seropositive subjects (NAÏVE and ART)(49.16 ± 5.49mm/hr and 24.12 ±2.88mm/hr) when compared to CTRL (7.66 ± 0.61 mm/hr). ART treatment resulted in a significant (P<0.05) decrease in ESR among seropositives. CRP concentration was significantly (P<0.05) increased in NAÏVE when compared to CTRL and subjects.

Conclusion: We conclude that Antiretroviral therapy in HIV-seropositive individuals acts to reinstall immune function and normalize fuction. Although immune function was not completely normalized, it was closer to normal than ART-naïve person whose immune function was largely compromised.

Item Type: Article
Subjects: ScienceOpen Library > Medical Science
Depositing User: Managing Editor
Date Deposited: 11 Feb 2023 06:45
Last Modified: 17 Jul 2024 09:39
URI: http://scholar.researcherseuropeans.com/id/eprint/432

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