Irfan, Shazia and Rani, Asima and Arshad, Muhammad and Nawaz, Syed Kashif and Sameem, Maryam and Liaqat, Iram (2016) Association of rs1800668 polymorphism in glutathione peroxidase- 1 gene and risk of rheumatoidarthritis in Pakistani population. Pakistan Journal of Medical Sciences, 32 (5). ISSN 1681-715X
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Abstract
Objective: To investigate the role of glutathione peroxidase 1 (GPX1) C/T polymorphism (rs1800668) in modulating the chances of Rheumatoid arthritis (RA) in Pakistani population.
Methods: A total of 400 individuals including 200 controls and 200 patients of RA, were genotyped. Detection of rs1800668 polymorphism was carried out using PCR based amplification strategy (allele specific).
Results: The results for Hardy Weinberg Equilibrium (HWE) indicated that the allele frequencies for GPX1 polymorphism were not deviant from HWE in whole population under observation. The statistical analysis indicated that significant association existed between rs1800668 polymorphism and RA (p<0.01). CT genotype increased the risk of RA development by 1.8582 times (OR: 1.8582; 95% CI 1.2154 to 2.8409). CC genotype was found to have protective effect against the disease development (OR: 0.5133; 95% CI 0.3403 to 0.7742) while TT genotype was found to have association with RA development but the risk level was marginal (OR: 1.5319; 95% CI 0.6124 to 3.8322).
Conclusion: The present finding suggests the importance of GPX1 C/T polymorphism (rs1800668) in development of RA in Pakistani population. The protective role of CC genotype against the development of RA in local population was also observed.
Item Type: | Article |
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Subjects: | ScienceOpen Library > Medical Science |
Depositing User: | Managing Editor |
Date Deposited: | 04 May 2023 05:33 |
Last Modified: | 14 Sep 2024 04:05 |
URI: | http://scholar.researcherseuropeans.com/id/eprint/1159 |